Ogutu, Bernhards (Prof.)

Ogutu, Bernhards (Prof.)

Director

Positions

Member, WWARN Parasite Clearance Study Group
Director, African Centre for Clinical Trials (ACCT)
Member, WWARN Gametocyte Study Group
Director, Council for Scientific and Industrial Research
Adjunct Professor, Institute of Healthcare Managemenent , Strathmore Business School
Director, Centre for Research in Therapeutic Sciences (CREATES) , Strathmore University 2009 -
Chief Research Officer, KEMRI-Welcomes TRUST 1995 -
Lead Clinical Collaborator, UNITED STATES ARMY MEDICAL RESEARCH DIRECTORATE-KENYA ( USAMRU-K ) 1995 -
Senior Clinical Trialist, Malaria Clinical Trials Alliance (MCTA), INDEPTH-Network - 2006
Part time lecturer, Department of Biomedical Sciences , Maseno University 2004 - 2005
Research Officer, Centre for Clinical Research 1999 - 2002
Lead Clinical Researcher, KEMRI-Welcomes TRUST - 1995

Research Areas

overview

MB ChB, M.Med, Ph.D.
Researcher and consultant.

member of

American Society of Tropical Medicine and Hygiene Member
Association of Clinical Research Professionals Member
East African Chapter of the Association of Clinical Research Professionals Founding Member
Kenya Medical Association Member
Kenya Paediatric Association Member
Board of Management Catholic University of Eastern Africa (CUEA) Member 2007 - 2010
Board of Management of the Uzima College of Health Sciences Member 2007 - 2010
External Scientific Advisory Committee (ESAC) Vice Chair 2008 - 2009
Expert Committee on Clinical Trials Kenya (ECCT) Member - 2007
KEMRI Parasitic Diseases Committee Member - 2005
National Malaria Technical Committee, Kenya Member - 2002

attended event

American Society of Tropical Medicine and Hygiene Annual Meeting 2004 - 2013
MIM Conference - 2013
Multilateral Initiative on Malaria (MIM) Conference 2008 - 2009

selected publications

abstract
academic article
- Building capability for clinical pharmacology research in sub-Saharan Africa. Clinical Pharmacology and Therapeutics . 786-795. 2017
- Longitudinal estimation of plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries. Malaria Journal. 2017
- Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. Malaria Journal. 2017
- Open-source mobile digital platform for clinical trial data collection in low-resource settings. BMJ Innovations. 2017
- Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART. Virology Journal. 2017
- Phase 2a, open-label, 4-escalating-dose, randomized multicenter study evaluating the safety and activity of Ferroquine (SSR97193) Plus Artesunate, versus Amodiaquine Plus Artesunate, in African adult men with uncomplicated plasmodium falciparum malaria.. American Journal of Tropical Medicine and Hygiene. 2017
- Plasma nevirapine concentrations predict virological and adherence failure in Kenyan HIV-1 infected patients with extensive antiretroviral treatment exposure. Public Library of Science (PLoS One). 12. 2017
- Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure. BMC Health Services Research Journal. 2017
- Safety and efficacy of SAR97276A for treating malaria: two open-label multicenter phase II clinical studies in African children and adults.. BMJ Global Health. 2017
- Safety and efficacy of the choline analogue SAR97276 for malaria treatment: results of two phase 2, open-label, multi-center trials in African patients. Malaria Journal. 2017
- The quest for building laboratory capacity to support controlled human malaria infection (CHMI) studies in sub-Saharan Africa: experience with five sites. British Medical Journal Open . 2017
- A multinational trial of Prasugrel for sickle cell vaso-occlusive events 2016
- Adenovirus type 35-vectored tuberculosis vaccine has an acceptable safety and tolerability profile in healthy, BCG-vaccinated, QuantiFERON-TB Gold (+) Kenyan adults without evidence of tuberculosis.. Vaccine Journal. 2016
- Changes in serological immunology measures in UK and Kenyan adults post-controlled human malaria infection. Frontiers in Microbiology. 2016
- Comparison of artesunate-mefloquine and artemether-lumefantrine fixed-dose combinations for treatment of uncomplicated Plasmodium falciparum malaria in children younger than 5 years in sub-Saharan Africa: a randomised, multicentre, phase 4 trial. The Lancet Infectious Diseases. 2016
- Field evaluation of diagnostic performance of malaria rapid diagnostic tests in western Kenya. Malaria Journal. 2016
- Glucose-6-phosphate dehydrogenase deficiency and reduced haemoglobin levels in African children with severe malaria. Malaria Journal. 2016
- Intramuscular artesunate for severe malaria in African children: a multicenter randomized controlled trial. PLoS Medicine. 2016
- Multi-country evaluation of safety of dihydroartemisinin/piperaquine post-licensure in African public hospitals with electrocardiograms. Public Library of Science (PLoS One). 2016
- Safety and immunogenicity of RTS,S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial. The Lancet Infectious Diseases. 2016
- Seeking treatment for uncomplicated malaria: experiences from the Kintampo districts of Ghana. Malaria Journal. 2016
- Treatment outcomes in a safety observational study of dihydroartemisinin/piperaquine (Eurartesim) in the treatment of uncomplicated malaria at public health facilities in four African countries. Malaria Journal. 2016
- Using health and demographic surveillance systems for teratovigilance in Africa. The Lancet Global Health. 2016
- Adult psychotic symptoms, their associated risk factors and changes in prevalence in men and women over a decade in a poor rural district of Kenya. International Journal of Environmental Research and Public Health. 12:5310-5328. 2015
- Alcohol consumption and hazardous drinking in western Kenya- a household survey in a health and demographic surveillance site. BMC Psychiatry. 2015
- Attention deficit hyperactivity disorder symptom self-report in adults in Kenya and its associated risk factors, an analysis from a household survey in a demographic surveillance site. Global Mental Health. 2015
- Characterization of Plasmodium ovale curtisi and P. ovale wallikeri in western Kenya utilizing a novel species-specific real-time PCR assay. PLoS Neglected Tropical Diseases. 2015
- Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data. BMC Medicine. 2015
- Co-infection burden of hepatitis C virus and Human Immunodeficiency Virus among Injecting heroin users at the Kenyan coast. Public Library of Science (PLoS One). 10. 2015
- Common mental disorder in Nyanza province, Kenya in 2013 and its associated risk factors - an assessment of change since 2004, using a repeat household survey in a demographic surveillance site. BMC Psychiatry. 2015
- Comparison of azithromycin plus chloroquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children in Africa: a randomized, open-label study. Malaria Journal. 2015
- Correlates of adherence and treatment failure among Kenyan patients on long-term highly active anti-retroviral therapy . AIDS Journal of Acquired Immune Deficiency Syndrome. 69. 2015
- Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. The Lancet Journal. 2015
- Evaluating controlled human malaria infection in Kenyan adults with varying degrees of Prior Exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection. Frontiers in Microbiology. 2015
- Feasibility and cost of using mobile phones for capturing drug safety information in peri-urban settlement in Ghana: a prospective cohort study of patients with uncomplicated malaria. Malaria Journal. 2015
- Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine. New England Journal of Medicine. 2015
- Genotypic variability of HIV-1 reverse transcriptase gene from long-term antiretroviral-experienced patients in Kenya. AIDS Research and Human Retroviruses. 2015
- HIV-1 subtype diversity based on envelope C2V3 sequences from Kenyan patients on highly active antiretroviral therapy. AIDS Research and Human Retroviruses. 2015
- Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial. The Lancet Infectious Diseases. 2015
- Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies. Malaria Journal. 2015
- Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem). Malaria Journal. 2015
- Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya. Malaria Journal. 2015
- Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice. International Journal of Nanomedicine. 2015
- P17.38 Plasma drug levels of nevirapine predict virological response in patients receiving treatment in Kenyan hospitals. BMC Sexually Transmitted Infections. 2015
- Prevalence of malaria parasites in adults and its determinants in malaria endemic area of Kisumu county, Kenya. Malaria Journal. 2015
- Probable post traumatic stress disorder in Kenya and its associated risk factors: a cross-sectional household survey. International Journal of Environmental Research and Public Health. 2015
- Prospective observational study to evaluate the clinical safety of the fixed-dose artemisinin-based combination Eurartesim (dihydroartemisinin/piperaquine), in public health facilities in Burkina Faso, Mozambique, Ghana, and Tanzania. Malaria Journal. 2015
- Provider compliance to artemisinin-based combination therapy at primary health care facilities in the middle belt of Ghana. Malaria Journal. 2015
- Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions--a prospective multicenter cohort study. BMC Medicine. 2015
- Tedium vitae, death wishes, suicidal ideation and attempts in Kenya-prevalence and risk factors health behavior, health promotion and society. BMC Public Health. 2015
- Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether-lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya. International Journal of Parasitology : Drugs and Drug Resistance. 2015
- The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data. The Lancet Infectious Diseases. 2015
- Use of antimalarial in the management of fever during a community survey in the Kintampo districts of Ghana. Public Library of Science (PLoS One). 2015
- Correlates of adherence and antiretroviral treatment failure in HIV-1 infected Kenyan patients. AIDS Research and Human Retroviruses. 2014
- Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles. International Journal of Nanomedicine. 3865-3874. 2014
- Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites. PLoS Medicine. 2014
- Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults. Malaria Journal. 2014
- Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study. Malaria Journal. 2014
- Fixed dose artesunate amodiaquine - a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine. Malaria Journal. 2014
- Health & demographic surveillance system profile: the Kombewa health and demographic surveillance system (Kombewa HDSS). International Journal of Epidemiology. 2014
- Longitudinal study on Plasmodium falciparum gametocyte carriage following artemether-lumefantrine administration in a cohort of children aged 12 - 47 months living in Western Kenya, a high transmission area. Malaria Journal. 2014
- Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: A phase II study. Malaria Journal. 2014
- Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunateamodiaquine. American Journal of Tropical Medicine and Hygiene. 2014
- Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles. International Journal of Nanomedicine. 3865-3874. 2014
- Sample-ready multiplex qPCR assay for detection of malaria. Malaria Journal. 2014
- The impact of clinical research activities on communities in rural Africa: the development of the Clinical Research Unit of Nanoro (CRUN) in Burkina Faso. Malaria Journal. 2014
- Impact, challenges, and future projections of vaccine trials in Africa. American Journal of Tropical Medicine and Hygiene. 2013
- Artemether and lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa. Expert Opinion in Pharmacotherapy. 2013
- Controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso. Malaria Journal. 2013
- Experience and challenges from clinical trials with malaria vaccines in Africa. Malaria Journal. 2013
- Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial. Journal of Critical Care. 2013
- Malaria mortality estimates: need for agreeable approach. Tropical Medicine and International Health. 2013
- Misclassification of Plasmodium infections by conventional microscopy and the impact of remedial training on the proficiency of laboratory technicians in species identification. Malaria Journal. 2013
- Results from tandem phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01. Malaria Journal. 2013
- A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. New England Journal of Medicine. 2012
- Development of a TaqMan Allelic Discrimination Assay for detection of Single Nucleotides Polymorphisms associated with anti-malarial drug resistance. Malaria Journal. 2012
- Mitigating the threat of artemisinin resistance in Africa: Improvement of drug-resistance surveillance and response systems. The Lancet Infectious Diseases. 2012
- Community screening and treatment of asymptomatic carriers of Plasmodium falciparum with artemether-lumefantrine to reduce malaria disease burden: a modelling and simulation analysis. Malaria Journal. 2011
- Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine. Malaria Journal. 2011
- First results of phase 3 Trial of RTS,S/AS01 Malaria vaccine in African children. New England Journal of Medicine. 2011
- Similar efficacy and safety of artemether-lumefantrine (Coartem) in African infants and children with uncomplicated falciparum malaria across different body weight ranges. Malaria Journal. 2011
- Evaluation of recurrent Parasitemia after Artemether-Lumefantrine treatment for uncomplicated Malaria in children in Western Kenya. American Journal of Tropical Medicine and Hygiene. 2010
- Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests. Malaria Journal. 2010
- Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malaria Journal. 2010
- Sustainable development of a GCP-compliant clinical trials platform in Africa: the Malaria Clinical Trials Alliance perspective. Malaria Journal. 2010
- The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria. Tropical Medicine and International Health. 2010
- Treatment of asymptomatic carriers with artemether-lumefantrine: an opportunity to reduce the burden of malaria. Malaria Journal. 2010
- Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in western Kenya. Public Library of Science (PLoS One). 2009
- Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area. Public Library of Science (PLoS One). 2009
- Malaria management - progress made and challenges still to face. Malaria Journal. 2009
- Population pharmacokinetics and pharmacodynamic considerations of Amodiaquine and Desethylamodiaquine in Kenyan adults with uncomplicated malaria receiving Artesunate-Amodiaquine combination therapy. Antimicrobial Agents and Chemotherapy. 2009
- A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in children in western Kenya. Malaria Journal. 2008
- Bullous erythema multiforme after treatment with Malarone, a combination antimalarial composed of atovaquone and proguanil hydrochloride. Tropical Doctor. 2008
- Data safety and monitoring boards for African clinical trials. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008
- Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial. The Lancet Journal. 2008
- Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study. The Lancet Neurology. 2008
- Malaria treatment with Atovaquone-proguanil in Malaria-Immune Adults: implications for malaria intervention trials and for pre-exposure prophylaxis of Malaria. Antimicrobial Agents and Chemotherapy. 2008
- Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions. British Journal of Clinical Pharmacology. 65:12-21. 2008
- Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions. British Journal of Clinical Pharmacology. 2008
- Pilot assessment of the sensitivity of the malaria thin film. Malaria Journal. 2008
- The content of African diets is adequate to achieve optimal efficacy with fixed-dose artemether-lumefantrine: A review of the evidence. Malaria Journal. 7. 2008
- Amodiaquine combined with sulfadoxine/pyrimethamine versus artemisinin-based combinations for the treatment of uncomplicated falciparum malaria in Africa: a meta-analysis. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2007
- Burden, features, and outcome of neurological involvement in acute Falciparum malaria in Kenyan children. Journal of the American Medical Association. 2007
- Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya. Malaria Journal. 2007
- Hb G-Philadelphia or Stanleyville II? When the phenotype and genotype do not agree. European Journal of Haematology. 2007
- Hb Kenya among Luo adults and young children in malaria holoendemic Western Kenya: screened by high performance liquid chromatography and confirmed by polymerase chain reaction 2007
- Implementation of a structured paediatric admission record for district hospitals in Kenya - results of a pilot study. BMC International Health and Human Rights. 2006
- Safety and reactogenicity of an MSP-1 malaria vaccine candidate: a randomized phase Ib dose-escalation trial in Kenyan children. PLoS Clinical Trials. 2006
- Systematic comparison of two methods to measure parasite density from malaria blood smears. Parasitology Research. 2006
- Chloramphenicol pharmacokinetics in African children with severe malaria. Journal of Tropical Pediatrics. 52:239-243. 2005
- Combination therapy in the treatment of malaria. East African Medical Journal. 82:385-386. 2005
- Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria. Malaria Journal. 2005
- Determination of lorazepam in plasma from children by high performance liquid chromatography with UV detection. Journal of Chromatography. 824:333-340. 2005
- The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the treatment of severe falciparum malaria in children. Tropical Medicine and International Health. 10:484-488. 2005
- Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine Journal. 2005
- Assessment of inpatient paediatric care in first referral level hospitals in 13 districts in Kenya. The Lancet Journal. 2004
- Determination of paraldehyde by gas chromatography in whole blood from children. Journal of Chromatography B. 805:365-369. 2004
- Management of seizures in children with Falciparum Malaria. Tropical Doctor. 2004
- Selective and sensitive liquid chromatographic assay of amodiaquine and desethylamodiaquine in whole blood spotted on filter paper. Journal of Chromatography B. 799:173-177. 2004
- Cerebral malaria: optimising management. CNS Drugs. 2003
- Hypothetical performance of syndrome-based management of acute paediatric admissions of children aged more than 60 days in a Kenyan district hospital. Bulletin of the World Health Organization (WHO). 2003
- Intention-to-treat analysis in the chronic suppurative otitis media trials. East Africa Medical Journal. 2003
- Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions. British Journal of Clinical Pharmacology. 56:453-458. 2003
- Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and convulsions. British Journal of Clinical Pharmacology. 56:112-119. 2003
- Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions. British Journal of Clinical Pharmacology. 2002
- Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol co-administration. British Journal of Clinical Pharmacology. 54:635-642. 2002
- High performance liquid chromatographic determination of diazepam in children with severe malaria. Journal of Chromatography B. 761:255-259. 2001
- Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. Clinical Infectious Diseases. 1998
- Azithromycin prophylaxis prevents epidemic dysentery. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1996
chapter
- Management of prolonged seizures. International child health care: a practical manual for hospitals worldwide. 2002
- Management of coma . International child health care: a practical manual for hospitals worldwide. Child Advocacy International.
conference paper
- Antibody responses to hepatitis B surface antigen following administration of RTS, S/AS01 E to HIV infected African infants and children background and aims. American Society of Tropical Medicine & Hygiene. 2016
editorial article
- Malaria diagnosis 2005

reviewer of

Clinical Pharmacology Journal (Journal)
East Africa Medical Journal (Journal)
New England Journal of Medicine (Journal)
The Lancet Journal (Journal)
Tropical Medicine and International Health (Journal)
Vaccine Journal (Journal)

contact or provider for service

External Examiner Analysis Service

organizer of event

Controlled Human Malaria Infection Studies - 2013
Clinical Trials Management - 2012
Nanotechnology Road Show - 2012
Malaria Diagnosis Training Workshops 2003 - 2010
Multilateral Initiative on Malaria (MIM) Conference - 2009
Pharmacogenetics of Drug Metabolising Enzymes - 2003
Pharmacokinetics and Herbal Medicines - 2003

education and training

Ph.D. in Clinical Pharmacology, University of Nairobi
M.Med. in Pediatrics, University of Nairobi 1995 - 1998
MB ChB Bachelor of Medicine, Bachelor of Surgery, University of Nairobi 1986 - 1991

credentials

Certified Facilitator, 2008
Certified Physician Investigator, 2007

awards and honors

MIM Scholarship, conferred by TDR, 1999

advisee of

graduate advising relationship
- Kokwaro, Gilbert O. (Prof.), Ph.D. candidacy, 2002

full name

Bernhards Ragama Ogutu

primary email

bernhards.ogutu@usamru-k.org

webpage

ORCID
ORCID

Publications in VIVO

Co-author Network

Contact Info

bernhards.ogutu@usamru-k.org

Websites

ORCID
ORCID